Excerpt from Robbwolf.com and Dr. Tim Jackson
Today, a variety of factors contribute to weakened immunity in the majority of the population
1) Heavy metals/toxic metals: Mercury, aluminum, lead, etc.
2) Pesticides, herbicides and other contaminants
3) Low body temperature
4) Hormonal imbalances: high cortisol/low DHEA, low cortisol/low DHEA, low thyroid function
5) Poor digestive health: imbalances in good:bad flora, mal-absorption, etc.
6) Epigenetic polymorphisms that are expressing: MTHFR, which is related to the production of certain types of immune cells known as T cells and GSTM/GSTP, which affects our levels of glutathione, an anti-oxidant important for immune function.
Addressing #1 and #2 involves optimizing Phase I and Phase II detoxification in the liver, as well as reducing exposure to these harmful compounds. Correcting #3 and #4 must involve a thorough examination of adrenal and thyroid health. An adrenal test known as an adrenal stress index should be performed to measure cortisol 4 times throughout the day, along with 2 measurements of DHEA. This is important for optimal body temperature because cortisol that is too high OR too low will negatively affect thyroid function. The following thyroid markers should be measured: free T3, free T4, TSH, reverse T3, anti-TPO antibodies, and anti-thyroglobulin antibodies. Optimizing digestion (#5) should include a baseline analysis, such as the Metametrix GI Effects Profile, to determine what abnormalities may exist in the beginning. These may include insufficient “good” bacteria, the presence of pathogenic microbes(yeast, bacteria, or parasites), low levels of stomach acid, or poor pancreatic enzyme output. Without optimizing gut health, it is difficult, if not impossible, to have a robust immune system. Lastly, testing for epigenetic polymorphisms can be done through 23andme(www.23andme.com) and putting your raw data through a program such as Genetic Genie, Prometheus, etc. can help you determine if you have any copies of immune-related polymorphisms such as MTHFR, GSTM, etc. Bypassing the MTHFR polymorphism is as simple as taking methylfolate, B12, and co-factors, such as the other B vitamins, magnesium, zinc, etc. full article
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